The Science Behind the Breakthrough
Explore 100+ peer-reviewed publications supporting our approach
Good science demands transparency. Here you'll find every published paper, clinical observation, and research finding that forms the foundation of our work.
What the Research Shows
Telomere Extension Study:
We measured telomeres (cellular aging markers) in 1,000+ patients. Result: Average 32% increase in length, equivalent to reversing 10-15 years of aging.
32%
Average telomere extension
Cognitive Function Research:
In 37 Alzheimer's patients, 89% maintained or improved their mental abilities over 24 months—remarkable compared to typical disease progression.
89%
Cognitive maintenance/improvement
Autoimmune Response:
90% of autoimmune patients reported significant symptom relief, with biomarkers showing reduced inflammation and improved immune regulation.
90%
Symptom relief reported
Peer-Reviewed Publications
Nature Family Publications
Tet2-mediated epigenetic drive for astrocyte differentiation from embryonic neural stem cells
Cell Death Discovery
Read Full Paper →Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease
Nature Medicine
Read Full Paper →Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells
Nature
Read Full Paper →Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing
Nature
Read Full Paper →The Aging Biomarker Consortium represents a new era for aging research in China
Nature Medicine
Read Full Paper →A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis
Nature Neuroscience
Read Full Paper →The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory
Nature Neuroscience
Read Full Paper →Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward
Nature Neuroscience
Read Full Paper →Knocking the NT4 gene into the BDNF locus rescues BDNF deficient mice and reveals distinct NT4 and BDNF activities
Nature Neuroscience
Read Full Paper →Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis
Nature Communications
Read Full Paper →Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease
Nature Communications
Read Full Paper →Eradication of specific donor-dependent variations of mesenchymal stem cells in immunomodulation to enhance therapeutic values
Cell Death & Disease
Read Full Paper →ATF5, a putative therapeutic target for the mitochondrial DNA 3243A > G mutation-related disease
Cell Death & Disease
Read Full Paper →Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics
Nature Chemical Biology
Read Full Paper →Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease
Nature Structural & Molecular Biology
Read Full Paper →Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury
Signal Transduction and Targeted Therapy
Read Full Paper →Quantification of O-glycosylation stoichiometry and dynamics using resolvable mass tags
Nature Chemical Biology
Read Full Paper →Safety and feasibility of 4-1BB co-stimulated CD19-specific CAR-NK cell therapy in refractory/relapsed large B cell lymphoma: a phase 1 trial
Nature Cancer
Read Full Paper →Chronic spinal cord injury repair by NT3-chitosan only occurs after clearance of the lesion scar
Signal Transduction and Targeted Therapy
Read Full Paper →Multi-omic profiling highlights factors associated with resistance to immuno-chemotherapy in non-small-cell lung cancer
Nature Genetics
Read Full Paper →Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines
Cell Discovery
Read Full Paper →Science Family Publications
DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation
Science
Read Full Paper →Regulation of Gliogenesis in the Central Nervous System by the JAK-STAT Signaling Pathway
Science
Read Full Paper →Dnmt3a-Dependent Nonpromoter DNA Methylation Facilitates Transcription of Neurogenic Genes
Science
Read Full Paper →Reversing DNA Methylation: New Insights from Neuronal Activity–Induced Gadd45b in Adult Neurogenesis
Science Signaling
Read Full Paper →Cell Family Publications
Neurogenin Promotes Neurogenesis and Inhibits Glial Differentiation by Independent Mechanisms
Cell
Read Full Paper →A Critical Role for DNA End-Joining Proteins in Both Lymphogenesis and Neurogenesis
Cell
Read Full Paper →Extensive Promoter-Centered Chromatin Interactions Provide a Topological Basis for Transcription Regulation
Cell
Read Full Paper →Single-Cell Transcriptome Analyses Reveal Signals to Activate Dormant Neural Stem Cells
Cell
Read Full Paper →Leukemia inhibitory factor mediates an injury response but not a target-directed developmental transmitter switch in sympathetic neurons
Neuron
Read Full Paper →An Antisense CAG Repeat Transcript at JPH3 Locus Mediates Expanded Polyglutamine Protein Toxicity in Huntington's Disease-like 2 Mice
Neuron
Read Full Paper →A Phenotypic Small-Molecule Screen Identifies an Orphan Ligand-Receptor Pair that Regulates Neural Stem Cell Differentiation
Chemistry & Biology
Read Full Paper →Destabilizing LSD1 by Jade-2 Promotes Neurogenesis: An Antibraking System in Neural Development
Molecular Cell
Read Full Paper →A combinatorial therapeutic approach to enhance FLT3-ITD AML treatment
Cell Reports Medicine
Read Full Paper →A Robust Single Primate Neuroepithelial Cell Clonal Expansion System for Neural Tube Development and Disease Studies
Stem Cell Reports
Read Full Paper →Immune pathway activation in neurons triggers neural damage after stroke
Cell Reports
Read Full Paper →PNAS Publications
A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone
PNAS
Read Full Paper →U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease
PNAS
Read Full Paper →Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function
PNAS
Read Full Paper →NT3-chitosan elicits robust endogenous neurogenesis to enable functional recovery after spinal cord injury
PNAS
Read Full Paper →MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life
PNAS
Read Full Paper →Single-cell RNA-seq analysis revealed long-lasting adverse effects of tamoxifen on neurogenesis in prenatal and adult brains
PNAS
Read Full Paper →α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation
PNAS
Read Full Paper →Nerve growth factor inhibits sympathetic neurons' response to an injury cytokine
PNAS
Read Full Paper →NT3-chitosan enables de novo regeneration and functional recovery in monkeys after spinal cord injury
PNAS
Read Full Paper →Phenotypic plasticity in adult sympathetic neurons: changes in neuropeptide expression in organ culture
PNAS
Read Full Paper →Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines
PNAS
Read Full Paper →Transcriptome analyses reveal molecular mechanisms underlying functional recovery after spinal cord injury
PNAS
Read Full Paper →TrkB neurotrophic activities are blocked by α-synuclein, triggering dopaminergic cell death in Parkinson's disease
PNAS
Read Full Paper →Spatiotemporally different origins of NG2 progenitors produce cortical interneurons versus glia in the mammalian forebrain
PNAS
Read Full Paper →Journal of Neuroscience
Full-Length Human Mutant Huntingtin with a Stable Polyglutamine Repeat Can Elicit Progressive and Selective Neuropathogenesis in BACHD Mice
Journal of Neuroscience
Read Full Paper →DNA Hypomethylation Perturbs the Function and Survival of CNS Neurons in Postnatal Animals
Journal of Neuroscience
Read Full Paper →Nerve Growth Factor Antiserum Induces Axotomy-Like Changes in Neuropeptide Expression in Intact Sympathetic and Sensory Neurons
Journal of Neuroscience
Read Full Paper →Deletion of Astroglial Dicer Causes Non-Cell-Autonomous Neuronal Dysfunction and Degeneration
Journal of Neuroscience
Read Full Paper →Depolarization increases vasoactive intestinal peptide- and substance P- like immunoreactivities in cultured neonatal and adult sympathetic neurons
Journal of Neuroscience
Read Full Paper →Additional Major Publications
Exploring the shared molecular mechanisms between systemic lupus erythematosus and primary Sjögren's syndrome based on integrated bioinformatics and single-cell RNA-seq analysis
Frontiers in Immunology
Read Full Paper →Neuroprotective Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells From Different Donors on Spinal Cord Injury in Mice
Frontiers in Cellular Neuroscience
Read Full Paper →Exercise Reverses Dysregulation of T-Cell-Related Function in Blood Leukocytes of Patients With Parkinson's Disease
Frontiers in Neurology
Read Full Paper →Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulated in Exercise in a Mouse Model of Parkinson's Disease
Frontiers in Aging Neuroscience
Read Full Paper →Notch signaling promotes astrogliogenesis via direct CSL-mediated glial gene activation
Journal of Neuroscience Research
Read Full Paper →Mutual regulation between GDF11 and TET2 prevents senescence of mesenchymal stem cells
Journal of Cellular Physiology
Read Full Paper →How the epigenome contributes to the development of psychiatric disorders
Developmental Psychobiology
Read Full Paper →A herbal medicine for Alzheimer's disease and its active constituents promote neural progenitor proliferation
Aging Cell
Read Full Paper →Melatonin alleviates lipopolysaccharide‐compromised integrity of blood–brain barrier through activating AMP‐activated protein kinase in old mice
Aging Cell
Read Full Paper →Single-cell transcriptomics reveals gene signatures and alterations associated with aging in distinct neural stem/progenitor cell subpopulations
Protein & Cell
Read Full Paper →Framework of biomarkers for vascular aging: a consensus statement by the Aging Biomarker Consortium
Life Medicine
Read Full Paper →Glycosylation of dentin matrix protein 1 is a novel key element for astrocyte maturation and BBB integrity
Protein & Cell
Read Full Paper →delta-secretase-truncated APP fragment activates CEBPB, mediating Alzheimer's disease pathologies
Brain
Read Full Paper →White Matter Structural and Network Topological Changes Underlying the Behavioral Phenotype of MECP2 Mutant Monkeys
Cerebral Cortex
Read Full Paper →Leptin resistance and obesity in mice with deletion of methyl-CpG-binding protein 2 (MeCP2) in hypothalamic pro-opiomelanocortin (POMC) neurons
Diabetologia
Read Full Paper →Can miRNAs in MSCs-EVs Offer a Potential Treatment for Hypoxic-ischemic Encephalopathy?
Stem Cell Reviews and Reports
Read Full Paper →Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells
Genes & Development
Read Full Paper →DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling
Development
Read Full Paper →Ago2 Immunoprecipitation Identifies Predicted MicroRNAs in Human Embryonic Stem Cells and Neural Precursors
PLOS One
Read Full Paper →Ngn1 inhibits astrogliogenesis through induction of miR-9 during neuronal fate specification
eLife
Read Full Paper →Prokineticin 2 Is a Target Gene of Proneural Basic Helix-Loop-Helix Factors for Olfactory Bulb Neurogenesis
Journal of Biological Chemistry
Read Full Paper →Sophisticated Magneto-Mechanical Actuation Promotes In Situ Stem Cell Assembly and Chondrogenesis for Treating Osteoarthritis
ACS Nano
Read Full Paper →Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear
Learning & Memory
Read Full Paper →Advancing the Science Together
We collaborate with leading research institutions worldwide to advance the field of cellular rejuvenation and longevity medicine.
UCLA
Research Partner
XPRIZE
Semi-Finalist
NIH
Grant Recipient
Nature
Published Author
Medical Disclaimer: Celljevity's Prometheus technology is currently investigational and not approved by the FDA. Treatment availability varies by jurisdiction. Individual results may vary. Please consult with your healthcare provider. The statements on this website have not been evaluated by the Food and Drug Administration. Our treatments are not intended to diagnose, treat, cure, or prevent any disease.